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Fig. 3 | BMC Bioinformatics

Fig. 3

From: De novo identification of maximally deregulated subnetworks based on multi-omics data with DeRegNet

Fig. 3

Conceptual view of subgraphs extracted by DeRegNet. A From a receptor node/root node (green cube) one can reach any node in the subnetwork. Nodes without any edges leading to other nodes (red triangles) of the subnetwork need to be elements of the so called terminal nodes. Generally, all nodes in the subgraph can be reached from the root node. B By reversing the orientation of the underlying network before applying DeRegNet, one can find subgraphs with only one terminal “root” node and multiple receptor nodes such that the terminal node can be reached from any other node in the subgraph. See Additional file 1: Supplementary Material and Methods for further details on applying DeRegNet in reverse mode

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