Fig. 7
From: De novo identification of maximally deregulated subnetworks based on multi-omics data with DeRegNet
Global upregulated subgraph for TCGA-LIHC reconstructs transcriptional activation of WNT signaling. The Color of nodes indicates the average \(\hbox {log}_2\) fold change of tumor samples compared to controls as represented in the color bar. The color of rims around nodes indicates genes contained in the integrin pathway (blue), the WNT pathway (yellow) and diverse other pathways (no rim). The color of edges indicates following interactions: activation (red), inhibition (dark blue), compound (brown), binding/association (yellow), indirect effect (dashed grey), phosphorylation (pink), dephosphorylation (light green), expression (green) and ubiquitination (light purple). See also Additional file 2: Figs. S6–S10