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Fig. 8 | BMC Bioinformatics

Fig. 8

From: De novo identification of maximally deregulated subnetworks based on multi-omics data with DeRegNet

Fig. 8

Global downregulated subgraph for TCGA-LIHC are centered on FOS and JUN transcription factors and drug metabolism. Color of nodes indicates the average \(\hbox {log}_2\) fold change of tumor samples compared to controls as represented by the color bar. The color of edges indicates the following interactions: activation (red), compound (brown), binding/association (yellow), indirect effect (dashed grey) and expression (green). Also noteworthy it the general connection of transcriptional activators and inhibitors to signaling as well as metabolic networks. Transcription regulators have been highlighted with an orange rim. See also Additional file 2: Figs. S12–S16

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