Fig. 6

Comparison of our method (SSRE) with the INSPEcT “first guess” on th same data. Top row: direct comparison (in log space) of rates obtained with our method and with the INSPEcT package on a single sample. Synthesis and processing rates are well correlated but not the degradation rate (Spearman correlation shown). The red bar indicates the diagonal. Bottom left: bars indicate the correlation of degradation rates with previously published data [27], as in Fig. 5. The INSPEcT method provides degradation rates with good correlation only for one of the three replicates (repl. 2), whereas it is the case for all three replicates using our method. The big dots indicate the slope of the regression line in log-log space (as in Fig. 5, left). Slopes obtained from SSRE estimates are closer to one, which correspond to the ideal case of a linear relationship between the (non-log) rates. Bottom center and right: Rates obtained with INSPEcT also reproduce the positive correlation between synthesis and processing rates, but they produce a negative correlation between synthesis and degradation rates, unlike our method (see Fig. 4, left) and previously published results. [27]