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Fig. 1 | BMC Bioinformatics

Fig. 1

From: An optimal variant to gene distance window derived from an empirical definition of cis and trans protein QTLs

Fig. 1

Histogram of log base 10 of the distance from lead SNP for GWAS of protein abundance to the transcription start site (TSS) of the cognate gene for that protein, for 2051 unique proteins from the study of Pietzner, et al. Four bins are used for each log unit. Solid red line represents the best fit Weibull distribution curve fit to all data points below 105.75. Solid blue line represents best fit random distribution curve fit to all pQTLs with a distance beyond above 106 base pairs. Dashed purple line represents best combined model starting from the parameters estimated for the initial Weibull curve and adding a Weibull fraction parameter to add the Weibull curve and the trans model curve

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BMC Bioinformatics

ISSN: 1471-2105

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