Empowering the discovery of novel target-disease associations via machine learning approaches in the open targets platform

Table 3 Top predicted indications for Ustekinumab

Ranking	Disease	Disease_ID	Prediction_score
1	Immune system disease	EFO_0000540	0.95580226
2	Asthma	EFO_0000270	0.94961476
3	Rheumatoid arthritis	EFO_0000685	0.9285401
4	Uveitis	EFO_1001231	0.8917595
5	Alopecia areata	EFO_0004192	0.8835659
6	Alzheimer's disease	EFO_0000249	0.8625836
7	Schizophrenia	EFO_0000692	0.862216
8	Atopic eczema	EFO_0000274	0.84960294
9	Takayasu arteritis	EFO_1001857	0.8476705
10	Temporal arteritis	EFO_1001209	0.8364161
11	Obesity	EFO_0001073	0.8306895
12	Multiple sclerosis	EFO_0003885	0.82465583
13	Osteoarthritis	EFO_0002506	0.8140218
14	Ulcerative colitis	EFO_0000729	0.8110609
15	Relapsing–remitting multiple sclerosis	EFO_0003929	0.7750288
16	Behcet's syndrome	EFO_0003780	0.75113726
17	Diabetes mellitus	EFO_0000400	0.74368954
18	Juvenile idiopathic arthritis	EFO_0002609	0.7401242
19	Non-alcoholic steatohepatitis	EFO_1001249	0.7374891
20	Systemic lupus erythematosus	EFO_0002690	0.73320544
21	Ankylosing spondylitis	EFO_0003898	0.7330974
22	Graft versus host disease	MONDO_0013730	0.72582567
23	Psoriatic arthritis	EFO_0003778	0.71739846
24	Alcohol dependence	EFO_0003829	0.71080697
25	Dermatitis	MONDO_0002406	0.7098975
26	Crohn's disease	EFO_0000384	0.6959177
27	HIV-1 infection	EFO_0000180	0.6868525
28	Periodontitis	EFO_0000649	0.6834563
29	Tuberculosis	Orphanet_3389	0.67681295
30	Post-traumatic stress disorder	EFO_0001358	0.6721301
31	Psoriasis	EFO_0000676	0.67159593
32	Viral disease	EFO_0000763	0.67042077
33	Cystic fibrosis	Orphanet_586	0.6682126
34	Abdominal Aortic Aneurysm	EFO_0004214	0.653386
35	Psoriasis vulgaris	EFO_1001494	0.63942015