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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Exploring kinase family inhibitors and their moiety preferences using deep SHapley additive exPlanations

Fig. 1

Clustering of features of eight kinase family inhibitors by Pearson’s \(r\). a Hierarchical clustering using Pearson’s \(r\) with the top 15 moiety features of each family, a combined total number of 44 moiety features. The color shed of the features indicate their SHAP importance score for each kinase family. Among the moiety features, we outline f-224 and f-225 in orange, for they have high SHAP scores for most of the eight families. We also refer to them as the common moieties. Moreover, the 9 family-specific moieties for EGFR are outlined in purple, and the 6 family-specific moieties for Akt are outlined in green. b The correlation coefficient between the features’ SHAP important scores and the odds ratios for four kinase families, one for each kinase group

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