Fig. 2

Average percentage of occurrence of different groups of moieties in the ligand of a cocrystal structure of a kinase belonging to a certain kinase family in the PDB and the kinase family inhibitors set. Subfigures a and b show the average percentage of occurrence of the two common moieties, the top-15 moieties per kinase family, and the bottom-29 moieties (notated as Remainder) for the 4 kinase families from different groups in PDB and Kinase family inhibitors sets, respectively. Subfigures c and d highlight the average percentage of occurrence of the family-specific moieties for the EGFR and Akt kinase families, in PDB and Kinase family inhibitors sets, respectively