Table 1 Regarding the interactome controllability, 6417 of the total nodes (74.6%) were classified as neutral; i.e., removing them will have no effect on the number of driver nodes in the network, representing the largest proportion of nodes in the interactome. 1391 (16.17% of the interactome) nodes were dispensable, meaning their removal would decrease the number of driver nodes in the network. Lastly, 793 nodes (9.2% of the interactome) were determined to be indispensable, which caused an increase in the need for driver nodes at their removal. In all three categories (i.e., betweenness centrality, degree, and housekeeping gene proportion), indispensable nodes had the highest value, followed by neutral, and dispensable with the lowest values

From: Elucidating gene expression patterns across multiple biological contexts through a large-scale investigation of transcriptomic datasets