Fig. 1

Construction of individual-specific different network. A A reference network is established through a set of control samples by PCC. A patient sample k includes a paired tumor sample (disease sample) and an adjacent normal tissues sample (control sample). A disease sample k is added to the reference network and constructed a Perturbed disease network (SSN in Disease). A Perturbed control network (SSN in Control) is obtained by a control sample k in the same way. The SSN is a sample-specific network. B Based on the theory of predecessors, the Disease network and Control network is constituted by the significance of each edge. The Sample-Specific Differential Network (SSDN) is constructed by quantifying above two networks’ differences