Table 1 Cociter mining analysis of top 30 LUSC candidate driver genes identified by DriverRWH (STRINGv10)
From: DriverRWH: discovering cancer driver genes by random walk on a gene mutation hypergraph
Genes | Co-appeared count | Is_Specificity | Rank position | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
Lung | Cancer | Driver | MutsigCV | Dawnrank | Gravity | OncodriveFML | Subdyquency | MinNetRank | ||
TP53 | 854 | 5942 | 55 | 1 | 1 | 1 | 527 | 3 | 1 | 3 |
TTN | 1 | 8 | 1 | 0 | 2 | 2771 | 3959 | 13,175 | NA | 1424 |
DNAH8 | 0 | 1 | 1 | 0 | 15 | 2 | NA | 2741 | 3 | 73 |
RYR2 | 3 | 3 | 2 | 0 | 4 | 492 | 400 | 11,456 | 2 | 1706 |
LRRK2 | 5 | 18 | 1 | 0 | 58 | 3 | 1556 | 10,604 | NA | 223 |
PTEN | 253 | 2597 | 35 | 1 | 26 | 6 | 588 | 2 | 14 | 44 |
PIK3CA | 94 | 576 | 13 | 1 | 22 | 36 | 2536 | 22 | 11 | 473 |
NOTCH1 | 84 | 486 | 23 | 1 | 49 | 24 | 1591 | 20 | 18 | 47 |
CSMD3 | 0 | 3 | 1 | 0 | 3 | 2434 | NA | 46 | NA | 940 |
ANK2 | 1 | 4 | 0 | 0 | 99 | 675 | 576 | 13,775 | NA | 4868 |
SYNE1 | 1 | 2 | 1 | 0 | 11 | 4 | 181 | 4035 | NA | 8653 |
KMT2D | 1 | 18 | 1 | 1 | NA | NA | 3147 | 1 | NA | 8656 |
DMD | 14 | 19 | 3 | 0 | 23 | 419 | 1998 | 11,399 | NA | 566 |
USH2A | 2 | 4 | 1 | 0 | 6 | 1136 | 4591 | 13,959 | NA | 215 |
OBSCN | 0 | 4 | 0 | 0 | 209 | 2458 | 204 | 9252 | NA | 1487 |
RYR1 | 0 | 3 | 1 | 0 | 53 | 64 | 1788 | 1299 | 4 | 590 |
NF1 | 12 | 137 | 8 | 1 | 52 | 2179 | 3255 | 2881 | 13 | 1106 |
LRP1B | 8 | 15 | 2 | 0 | 5 | 2397 | 399 | 9317 | NA | 1471 |
APOB | 3 | 23 | 1 | 0 | 84 | 388 | 253 | 8676 | NA | 1465 |
RELN | 0 | 9 | 2 | 0 | 113 | 172 | 40 | 13,119 | NA | 3089 |
MYH1 | 1 | 14 | 1 | 0 | 122 | 630 | NA | 6933 | NA | 2615 |
EPHA5 | 2 | 6 | 1 | 0 | 172 | 8 | NA | 7697 | 28 | 90 |
MYH2 | 4 | 3 | 1 | 0 | 44 | 98 | NA | 5025 | 7 | 2538 |
KDR | 105 | 207 | 3 | 0 | 131 | 22 | 549 | 2832 | 71 | 43 |
HERC2 | 0 | 14 | 1 | 0 | 155 | 5624 | 148 | 8436 | 15 | 2403 |
POTEE | 1 | 9 | 0 | 0 | 1153 | 40 | 3138 | 8733 | 67 | 229 |
PIK3CG | 36 | 119 | 1 | 0 | 426 | 21 | 602 | 8186 | 51 | 234 |
CPS1 | 2 | 6 | 1 | 0 | 71 | 5 | 3852 | 13,518 | NA | 387 |
KMT2C | 3 | 21 | 4 | 1 | NA | NA | 5041 | 479 | NA | 4264 |
HDAC9 | 5 | 18 | 1 | 0 | 371 | 1640 | 3783 | 10,894 | 85 | 944 |