Table 2 Cociter mining analysis of top 30 BRCA candidate driver genes identified by DriverRWH (STRINGv10)
From: DriverRWH: discovering cancer driver genes by random walk on a gene mutation hypergraph
Genes | Co-appeared count | Is_Specificity | Rank position | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
Breast | Cancer | Driver | MutsigCV | Dawnrank | Gravity | OncodriveFML | Subdyquency | MinNetRank | ||
TP53 | 1177 | 5942 | 55 | 1 | 1 | 1 | 884 | 5 | 2 | 24 |
PIK3CA | 170 | 576 | 13 | 1 | 2 | 4 | 3949 | 9885 | 1 | 200 |
CDH1 | 291 | 1143 | 13 | 1 | 3 | 2 | 448 | 6 | 4 | 52 |
GATA3 | 84 | 114 | 4 | 1 | 4 | 11 | 179 | 1 | NA | 8652 |
TTN | 2 | 8 | 1 | 0 | NA | 3148 | 197 | 16,438 | 3 | 6097 |
PTEN | 595 | 2597 | 35 | 1 | 6 | 3 | 300 | 7 | 10 | 42 |
MAP3K1 | 59 | 129 | 2 | 1 | 5 | 122 | 208 | 4 | 5 | 528 |
KMT2C | 3 | 21 | 4 | 1 | NA | NA | 2121 | 3 | NA | 4076 |
DNAH8 | 0 | 1 | 1 | 0 | 115 | 7 | NA | 1942 | 78 | 122 |
AKT1 | 477 | 1863 | 13 | 1 | NA | 6 | 1226 | 2233 | NA | 31 |
OBSCN | 1 | 4 | 0 | 0 | NA | 1724 | 642 | 15,684 | 14 | 1760 |
DMD | 1 | 19 | 3 | 0 | 16 | 17 | 1457 | 5795 | 11 | 827 |
NF1 | 19 | 137 | 8 | 1 | 13 | 998 | 1641 | 25 | 34 | 926 |
UBC | 176 | 653 | 4 | 0 | 197 | 29 | NA | 2704 | 38 | 16 |
PRDM10 | 1 | 1 | 2 | 0 | 916 | 21 | 4104 | 49 | 560 | 27 |
ERBB2 | 3631 | 4422 | 36 | 1 | 126 | 5 | 1465 | 35 | 33 | 51 |
MYH9 | 10 | 32 | 4 | 0 | 30 | 358 | 1540 | 4141 | NA | 476 |
NCOR1 | 16 | 58 | 2 | 1 | 9 | 2903 | 76 | 22 | 7 | 3160 |
FOXA1 | 82 | 128 | 5 | 1 | 26 | 26 | 33 | 21 | NA | 8660 |
ANK3 | 3 | 4 | 2 | 0 | NA | 3251 | 2415 | 4803 | 54 | 2288 |
LRRK2 | 4 | 18 | 1 | 0 | 218 | 39 | 7388 | 3480 | 278 | 270 |
MTOR | 321 | 1896 | 21 | 0 | NA | 22 | 664 | 1419 | 47 | 115 |
EGFR | 722 | 4091 | 94 | 0 | NA | 10 | 2909 | 14,413 | 1195 | 35 |
RYR2 | 2 | 3 | 2 | 0 | NA | 1689 | 2525 | 12,929 | 9 | 2197 |
PRKDC | 57 | 274 | 4 | 0 | 77 | 12 | 127 | 9326 | 51 | 312 |
ANK2 | 0 | 4 | 0 | 0 | NA | 405 | 3532 | 971 | 44 | 4349 |
ASH1L | 0 | 2 | 1 | 0 | 109 | 5672 | 957 | 6540 | 85 | 2723 |
KDM6A | 5 | 24 | 3 | 0 | 64 | 5042 | 2140 | 78 | NA | 2380 |
SYNE1 | 0 | 2 | 1 | 0 | NA | 1801 | 1233 | 12,287 | NA | 8654 |
RUNX1 | 14 | 110 | 6 | 1 | 7 | 2058 | 748 | 17 | 28 | 3175 |