Table 3 Cociter mining analysis of top 30 UCEC candidate driver genes identified by DriverRWH (STRINGv10)
From: DriverRWH: discovering cancer driver genes by random walk on a gene mutation hypergraph
Genes | Co-appeared count | Is_Specificity | Rank position | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
Endometrial | Cancer | Driver | MutsigCV | Dawnrank | Gravity | OncodriveFML | Subdyquency | MinNetRank | ||
PTEN | 380 | 2597 | 35 | 1 | 1 | 1 | 233 | 168 | 1 | 9 |
TP53 | 143 | 5942 | 55 | 1 | 2 | 2 | 1687 | 403 | 4 | 43 |
PIK3CA | 39 | 576 | 13 | 1 | 3 | 34 | 2 | 673 | 2 | 73 |
CTNNB1 | 112 | 2014 | 29 | 1 | 5 | 5 | 10 | 22 | 11 | 42 |
KRAS | 51 | 2538 | 95 | 1 | 4 | 93 | 1787 | 8653 | 14 | 218 |
DNAH8 | 0 | 1 | 1 | 0 | 3741 | 6 | 6012 | NA | 24 | 44 |
LRRK2 | 0 | 18 | 1 | 0 | 2433 | 13 | NA | 7114 | 45 | 110 |
OBSCN | 0 | 4 | 0 | 0 | 1171 | 2641 | 5199 | 2055 | NA | 1184 |
PRDM10 | 0 | 1 | 2 | 0 | 7658 | 42 | NA | 992 | 479 | 36 |
RANBP2 | 0 | 12 | 1 | 0 | 148 | 164 | 40 | 1176 | 32 | 176 |
NOTCH1 | 15 | 486 | 23 | 1 | 61 | 18 | 7054 | 2680 | 94 | 45 |
TAF1 | 0 | 9 | 1 | 0 | 45 | 7954 | 5227 | 171 | NA | 8657 |
ARID1A | 14 | 67 | 4 | 1 | 31 | 5994 | 4505 | 2 | 3 | 1260 |
ANK3 | 0 | 4 | 2 | 0 | 216 | 5214 | 5808 | 157 | NA | 1914 |
ATM | 4 | 1222 | 5 | 1 | 241 | 54 | 1097 | 493 | 16 | 148 |
ALB | 0 | 32 | 1 | 0 | 7085 | 25 | 7566 | 7390 | 397 | 37 |
EP300 | 2 | 145 | 2 | 0 | 18 | 151 | 79 | 17 | 54 | 430 |
DMD | 0 | 19 | 3 | 0 | 180 | 69 | 2776 | 3448 | NA | 508 |
MTOR | 63 | 1896 | 21 | 1 | 182 | 112 | NA | 1308 | 95 | 63 |
PRKDC | 3 | 274 | 4 | 0 | 337 | 40 | 1217 | 41 | 28 | 130 |
CTCF | 2 | 50 | 3 | 1 | 1214 | 29 | 24 | 19 | NA | 164 |
TTN | 0 | 8 | 1 | 0 | 12 | 7696 | 3 | 1195 | NA | 4116 |
FGFR2 | 23 | 294 | 5 | 1 | 177 | 55 | 4875 | 1394 | 43 | 80 |
CAD | 0 | 40 | 1 | 0 | 17 | 27 | 7174 | 1091 | 122 | 51 |
NSD1 | 0 | 16 | 2 | 1 | 1167 | 53 | 34 | 631 | 21 | 85 |
ASH1L | 0 | 2 | 1 | 0 | 1279 | 4694 | 4260 | 3296 | 49 | 2436 |
TRRAP | 0 | 26 | 1 | 0 | 81 | 299 | 8 | 96 | 30 | 303 |
POTEE | 0 | 9 | 0 | 0 | 4902 | 155 | NA | 4873 | 171 | 146 |
GLI3 | 2 | 36 | 2 | 0 | 21 | 20 | 2263 | 3088 | NA | 104 |
KMT2D | 0 | 18 | 1 | 1 | 23 | NA | NA | 3113 | NA | 8652 |