Practical application of a Bayesian network approach to poultry epigenetics and stress

BMC Bioinformatics

Table 1 Features of interest discovered via Bayesian network

Symbol	Gene	Identified by	Gene information
OCLN	Occludin	Markov Blanket	Intracellular tight junctions and adhesion. Limiting (allowing/preventing) the exchange of substances and/or cells
CANX	Calnexin	Highest probability values	Role when unfolded/misfolded proteins exceed the capacity of chaperones. Functionality associated with the resistance of the blood brain barrier
FBN1	Fibrillin-1	Highest probability values	Component of microfibrils which make up extracellular matrix protecting cells, including nerve cells
TPST 1 / TPST 2	Tyrosyl protein sulfotransferases	Highest probability values	Both proteins are in charge of the correct functioning of PSLG-1 (P-selectin), which promotes adhesive interactions with other selectins that might lead to inflammatory diseases
ENS51236	None	Markov Blanket	Function yet unknown
ENS27231	None	Highest probability values	Function yet unknown
DMR7	None	Highest probability values	Function yet unknown

The DMR name (see “Methods” Section) as shown in the network in Fig. 4 is provided in the ‘Symbol’ column; the gene name (if existing) in ‘Gene’, and the remaining two columns represent how we identified this feature of interest from the network structure and information about gene function, respectively

ISSN: 1471-2105