Fig. 6
EpiConv better aligns leukemic cells to normal hematopoiesis a Low dimensional embedding of epiConv before and after integration. HSC, hematopoietic stem cell; MPP, multipotent progenitors; LMPP lymphoid-primed multipotent progenitor; GMP, granulocyte-macrophage progenitor; MEP, megakaryocyte-erythroid progenitor; CLP, common lymphoid progenitor; Ery biased MPP, erythroid biased MPP; pDC, plasmacytoid dendritic cell; CMP, common myeloid progenitor, T biased prog, T cell biased progenitor; Unk prog, unknown progenitor. b The LISI metric of different methods. c Low dimensional embeddings of cisTopic, LSI, SCALE and SnapATAC after Seurat batch correction. d Sub-clusters of C01 with increased accessibility in PU.1 or GATA1 motifs and two lymphoid primed clusters (CLP and T biased prog). Malignant cells of MPAL4 projected to these four clusters were shown. e Cluster-specific markers shared by normal cells and malignant cells of MPAL4. f MPPGATA1 signatures of normal cells and MPAL4 on the embedding of epiConv and LSI + Seurat.