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Fig. 3 | BMC Bioinformatics

Fig. 3

From: SEMplMe: a tool for integrating DNA methylation effects in transcription factor binding affinity predictions

Fig. 3

SEMplMe output for JUN varies between cell types. SEM plots vary more between cell types when only considering methylated sites (top right) than methylated and unmethylated sites (bottom left) (correlation comparison: HepG2 v. H1-hESC p-value <  = 0.01, HepG2 v. K562 p-value <  = 0.01, H1-hESC v. K562 p-value <  = 0.07). This suggests methylation plays a key role in the cell type specificity of the transcription factor JUN

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BMC Bioinformatics

ISSN: 1471-2105

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