Fig. 6

SEMplMe has higher correlation with in vivo CTCF binding than Methyl-Spec-seq. A. A and B. SEMplMe outperforms Methyl-Spec-seq when comparing to CTCF ChIP-seq scores for whole kmers, including methylated sites (SEMplMe R² = 0.25, Methyl-Spec-seq R² = 0.04, correlation comparison p-value <  = 0.01). C–E. SEMplMe is more closely inversely correlated with methylation occupancy in CTCF binding sites from an Illumina 450 k microarray dataset compared to SEMpl without methylation, and Methyl-Spec-seq (SEMplMe R² = 0.176, SEMpl R² = 0.04, Methyl-Spec-seq R² = 0.096, correlation comparison p-values > 0.132). Grey ribbons represent Pearson’s 0.95 CI