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Fig. 6 | BMC Bioinformatics

Fig. 6

From: SEMplMe: a tool for integrating DNA methylation effects in transcription factor binding affinity predictions

Fig. 6

SEMplMe has higher correlation with in vivo CTCF binding than Methyl-Spec-seq. A. A and B. SEMplMe outperforms Methyl-Spec-seq when comparing to CTCF ChIP-seq scores for whole kmers, including methylated sites (SEMplMe R2 = 0.25, Methyl-Spec-seq R2 = 0.04, correlation comparison p-value <  = 0.01). CE. SEMplMe is more closely inversely correlated with methylation occupancy in CTCF binding sites from an Illumina 450 k microarray dataset compared to SEMpl without methylation, and Methyl-Spec-seq (SEMplMe R2 = 0.176, SEMpl R2 = 0.04, Methyl-Spec-seq R2 = 0.096, correlation comparison p-values > 0.132). Grey ribbons represent Pearson’s 0.95 CI

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