Fig. 8
From: Transforming L1000 profiles to RNA-seq-like profiles with deep learning
Volcano plots of signatures of CRISPR knockouts and chemical perturbagens that are predicted to up- or down-regulate SFRP2 (A, B) and LGI3 (C, D). The x-position indicates the log2(fold change) of the expression of the query gene in the CRISPR knockouts and chemical perturbagen signatures, while the y-position indicates the absolute CD coefficient of the gene. The plots highlight points with the same-direction fold change and CD coefficient values by coloring them blue (up-regulated) or red (down-regulated). Darker colored points indicate signatures where the query gene is differentially expressed with a larger absolute value of the CD-coefficient and fold change