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Table 4 Summary performance of these SNP-set based association methods in the power evaluation of simulation studies and in real-data applications to distinct fields

From: A comprehensive comparison of multilocus association methods with summary statistics in genome-wide association studies

 

Common variants

Rare variants

Unweighted

TWAS with eQTL weights

No horizontal pleiotropy

Horizontal pleiotropy

Simulation

HMP

ACAT

BT

HMP

ACAT

SKAT

SKATO

Application

HMP

ACAT

HMP

SKATO

 

SKAT

SKATO

  1. The methods listed in the table were selected in terms of their power in the simulation studies or based on the number of identified genes in the real-data applications