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Table 6 Identified genes associated with six psychiatric disorders, four plasma lipid traits and nine immune-related diseases under various real-data applications

From: A comprehensive comparison of multilocus association methods with summary statistics in genome-wide association studies

Phenotype

BT

SKATO

SKAT

Simes

minP

HMP

ACAT

Total

Six psychiatric disorders under the context of common variant association analysis

ADHD

6

25

25

24

25

27

26

36

ASD

1

4

3

2

2

3

3

5

BIP

7

65

74

57

59

81

80

116

CU

0

10

12

10

11

14

14

16

MDD

2

10

9

1

3

5

5

13

SCZ

11

282

299

295

299

307

298

402

Four plasma lipid traits within the framework of rare variant association analysis

HDL

22

221

222

193

192

239

215

282

LDL

65

147

152

146

147

150

144

198

TG

78

203

205

168

168

168

168

209

TC

146

219

218

198

198

197

198

252

Nine immune-related diseases under the setting of TWAS analysis

IBD

22

146

94

  

253

249

292

UC

13

175

129

  

222

219

271

CD

22

222

144

  

282

272

357

SLE

101

180

104

  

267

266

315

PBC

102

149

65

  

122

121

240

PSC

92

210

138

  

223

221

298

RA

46

157

139

  

165

141

217

MS

106

137

183

  

205

201

306

OST

10

36

0

  

5

5

49

  1. The maximum number of associated genes is highlighted in bold for each disease. Methods including Simes and minP which cannot incorporate eQTL weights were excluded from the TWAS analysis of the nine immune-related diseases
  2. ADHD Attention-deficit/hyperactivity disorder, ASD Autism spectrum disorder, BIP Bipolar disorder, CU Cannabis use, MDD Major depression disorder, SCZ Schizophrenia, HDL High-density-lipoprotein cholesterol, LDL Low-density-lipoprotein cholesterol, TG Triglycerides, TC Total cholesterol, IBD Inflammatory bowel disease, UC Ulcerative colitis, CD Crohn’s disease, SLE Systemic lupus erythematosus, PBC Primary biliary cirrhosis, PSC Primary sclerosing cholangitis, RA Rheumatoid arthritis, MS Multiple sclerosis, OST Osteoarthritis