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Fig. 3 | BMC Bioinformatics

Fig. 3

From: DMRscaler: a scale-aware method to identify regions of differential DNA methylation spanning basepair to multi-megabase features

Fig. 3

Differential Methylation Analysis Between XX and XY individuals. A Hilbert Curves of chrX and chr1. Hilbert curve is constructed by ordering CpGs by their position along the given chromosome. Red points are differentially methylated CpGs with FDR < 0.1. Point size scaled to max significance level (-log10 p-value). B Diagonal network plots showing hierarchical relation of DMRs called by DMRscaler in Layers 4, 3, 2, and 1 (equivalent to 32 16, 8, and 4 Adj. CpG Layers respectively) for X-chromosome. C ChrX:71.4–71.6 Mb. GVIZ track stack plot. Top track shows mean β value per group, next track shows Δβ, where Δβ = βfemale−βmale. Below the gene model track is the DMR track, highlighting the regions called as a DMR at each result layer from DMRscaler (Layers 1, 2, 3, 4, 5 are equivalent to 4, 8, 16, 32, 64 Adj. CpG layers) and from each competing method. (D) Chr9:84.302–84.306 Mb. Tracks same as 3C

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