Fig. 5

Differential Methylation Analysis in Weaver (A,B,C) and Sotos Syndrome (D,E,F). A Hilbert curve of CpGs from chr7, outlined is the region corresponding to Chr7:27.1–27.3 Mb, the HOXA cluster. CpGs with FDR < 0.1 are highlighted red. Point size is scaled to maximum significance value. B Chr7:27.1–27.3 Mb. HOXA cluster. GVIZ track stack plot. Top track shows mean β value per group, next track shows Δβ, where Δβ = β_Control−β_Weaver. Below the gene model track is the DMR track, highlighting the regions called as a DMR at each result layer from DMRscaler and from each competing method. C Chr5:140.1–140.8 Mb over the PCDH clusters. Design same as 4A. D.Chr5:140.1–140.8 Mb over the PCDH clusters. Tracks same as 4B. except that Δβ = β_Control−β_Sotos