Fig. 1
From: Boolean implication analysis of single-cell data predicts retinal cell type markers
Schematic algorithm. Schematic algorithm to discover cell type-specific genes from scRNA-seq data by combining correlational and Boolean implication analysis. Boolean implication analysis uses one general and one specific bait gene to identify cell type-specific biomarkers. Spearman’s rank correlation coefficient analysis (SRCCA) uses one or more genes specific to a cell type as bait genes to identify other genes expressed in the same cell type. Boolean analysis is directly compared to SRCCA and improvement is tested using two proportion Z-test