Fig. 4
From: Atlas of regulated target genes of transcription factors (ART-TF) in human ES cells
Activating and repressing effects of TFs. A Number of TFs with varying proportion of upregulated target genes after TF induction. B Number of TFs with varying proportion of upregulated genes after TF induction (> twofold, FDR < 0.05). C Number of TFs with varying proportion of upregulated genes in the TRRUST database. D The proportion of target genes regulated by binding of individual TFs to enhancers, promoters, and enhancers + promoters in four groups of TFs: strong activators, moderate activators, moderate repressors and strong repressors. E Average proportion of promoter-bound and enhancer-promoter loop bound target genes in the same four groups of TFs as in (D). Vertical lines show SD based on one-way ANOVA; statistical significance of pairwise comparison of means: (*) p < 0.05, (**) p < 0.01. F The proportion of regulated targets of each TF among genes that responded to the induction of the same TF (> twofold change, FDR < 0.05) plotted against the number of genes that responded to the induction of the TF. Upregulated genes are shown for activator TFs and downregulated genes—for repressing TFs