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Table 10 The 5 enriched pathways using the list of relevant down regulated DEGs obtained from the Alzheimer GSE16759 data set

From: A statistical network pre-processing method to improve relevance and significance of gene lists in microarray gene expression studies

PathwayName

Pvalue

FDRC

BonfC

\(|lg_{2}(P_{value})|\)

\(|lg_{2}(FDR(P_{value})|\)

\(|lg_{2}Bonf(P_{value})|\)

1) Synthesis of 5-eicosatetraenoic acids

0.002

0.013

0.735

6.23

0.45

0.45

2) Synthesis of leukotrienes (LT) and eoxins (EX)

0.002

0.014

0.764

6.20

0.39

0.39

3) HIV transcription initiation

0.003

0.026

1.000

5.28

0.00

0.00

4) RNA Polymerase II HIV promoter escape

0.003

0.025

1.000

5.30

0.00

0.00

5) Transcription of the HIV genome

0.005

0.037

1.000

4.76

0.00

0.00

  1. The FDRC indicates the corrected p value using FDR statistical corrector. The BonfC represents the corrected p value using Bonferroni statistical corrector. Finally, the last three columns contain the \(|lg_{2}(\cdot )|\) of each p value, for ease comparison