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Table 7 The first 10 enriched pathways using the list of relevant up regulated DEGs obtained from the AML GSE24739 data set

From: A statistical network pre-processing method to improve relevance and significance of gene lists in microarray gene expression studies

PathwayName

Pvalue

FDRC

BonfC

\(|lg_{2}(P_{value})|\)

\(|lg_{2}(FDR(P_{value})|\)

\(|lg_{2}Bonf(P_{value})|\)

(1) Hemostasis

1.82E−11

1.60E−08

1.60E−08

35.68

25.89

25.89

(2) Signaling pathways

4.32E−10

1.91E−07

3.81E−07

31.11

22.32

21.32

(3) Metabolism of proteins

4.09E−08

1.20E−05

3.61E−05

24.54

16.34

14.76

(4) Muscle contraction

4.13E−08

9.11E−06

3.64E−05

24.53

16.74

14.74

(5) Cell cycle, mitotic

1.18E−07

2.09E−05

1.04E−04

23.01

15.55

13.23

(6) Mitotic G1 phase and G1/S transition

1.18E−07

1.74E−05

1.04E−04

23.01

15.81

13.23

(7) Cardiac conduction

1.55E−07

1.95E−05

1.36E−04

22.62

15.65

12.84

(8) Cell Cycle

1.78E−07

1.96E−05

1.57E−04

22.42

15.64

12.64

(9) Nervous system development

2.29E−07

2.24E−05

2.02E−04

22.06

15.45

12.28

(10) Amino acid and derivative metabolism

2.88E−07

2.54E−05

2.54E−04

21.73

15.26

11.94

  1. The FDRC indicates the corrected p value using FDR statistical corrector. The BonfC represents the corrected p value using Bonferroni statistical corrector. Finally, the last three columns contain the \(|lg_{2}(\cdot )|\) of each p value, for ease comparison