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Table 8 The first 10 enriched pathways using all genes obtained from GEO2R enclosed in the AML GSE24739 data set, without using the proposed pre-processing method

From: A statistical network pre-processing method to improve relevance and significance of gene lists in microarray gene expression studies

PathwayName

Pvalue

FDRC

BonfC

\(|lg_{2}(P_{value})|\)

\(|lg_{2}(FDR(P_{value})|\)

\(|lg_{2}Bonf(P_{value})|\)

(1) Signaling pathways

7.67E−303

3.01E−301

1.92E−299

1003.606

998.313

992.313

(2) Generic transcription pathway

7.67E−303

3.01E−301

1.92E−299

1003.606

998.313

992.313

(3) Gene expression (transcription)

7.67E−303

3.01E−301

1.92E−299

1003.606

998.313

992.313

(4) SLC-mediated transmembrane transport

7.67E−303

3.01E−301

1.92E−299

1003.606

998.313

992.313

(5) Cellular responses to stimuli

7.67E−303

3.01E−301

1.92E−299

1003.606

998.313

992.313

(6) Cellular responses to stress

7.67E−303

3.01E−301

1.92E−299

1003.606

998.313

992.313

(7) Cellular senescence

7.67E−303

3.01E−301

1.92E−299

1003.606

998.313

992.313

(8) DNA damage-telomere stress induced senescence

7.67E−303

3.01E−301

1.92E−299

1003.606

998.313

992.313

(9) Carbohydrate metabolism

7.67E−303

3.01E−301

1.92E−299

1003.606

998.313

992.313

(10) Metabolism

7.67E−303

3.01E−301

1.92E−299

1003.606

998.313

992.313

  1. .The FDRC indicates the corrected p value using FDR statistical corrector. The BonfC represents the corrected p value using Bonferroni statistical corrector. Finally, the last three columns contain the \(|lg_{2}(\cdot )|\) of each p value, for ease comparison