Small molecule modulation of microbiota: a systems pharmacology perspective

BMC Bioinformatics

Table 1 Hypergeometric test on drugs based on drug category information in Drugbank

Categories	p Value	Bonferroni corrected p value	B&H FDR adjusted p value	B&Y FDR adjusted p value
Nitric oxide synthase antagonists & inhibitors	0.00000	0.00012	0.00012	0.00082
Urea	0.00000	0.00029	0.00014	0.00094
Sulfonylureas	0.00004	0.01525	0.00508	0.03327
Oral hypoglycemics	0.00007	0.02843	0.00711	0.04652
Drugs used in diabetes	0.00018	0.06979	0.01204	0.07882
Sulfonylurea compounds	0.00019	0.07226	0.01204	0.07882
Stereoisomerism	0.00023	0.08839	0.01263	0.08264
Aldehyde reductase, antagonists & inhibitors	0.00041	0.16059	0.02007	0.13138
Enzyme inhibitors	0.00047	0.18206	0.02023	0.13239
Blood glucose lowering agents	0.00061	0.23983	0.02398	0.15696
Pyrazoles	0.00135	0.52458	0.04769	0.31211

Only the categories with Bonferroni corrected p value, B&H FDR adjusted p value, or B&Y FDR adjusted p-value lower than 0.05 are shown

ISSN: 1471-2105