Table 1 Parameters specifications of the 9 simulation settings
Setting | πH | Know mediator effects | Sample size | Number of known mediators | Associations among mediators | Level 1 and Level 2 standard deviation ratios | Hidden mediator effect | Number of SNPs |
|---|---|---|---|---|---|---|---|---|
Base case | 0.8 | (0.4, 0.2, 0.3, 0.2, 0.4) | 100,000 | 5 | Independent | 0:1 | Non-zero | 70; 500 |
Setting 1 | 0.3; 0.5; 1 | (0.4, 0.2, 0.3, 0.2, 0.4) | 100,000 | 5 | Independent | 0:1 | Non-zero | 70; 500 |
Setting 2 | 0.8 | (0.4, 0.2, 0.3, -0.2, -0.4) | 100,000 | 5 | Independent | 0:1 | Non-zero | 70; 500 |
Setting 3 | 0.8 | (0.4, 0.2, 0.3, 0.2, 0.4) | 25,000; 50,000 | 5 | Independent | 0:1 | Non-zero | 70; 500 |
Setting 4 | 0.8 | (0.4); (0.4, 0.2, 0.3, 0.2, 0.4, 0.2, 0.1, 0.3, 0.2, 0.2) | 100,000 | 1; 10 | Independent | 0:1 | Non-zero | 70; 500 |
Setting 5 | 0.8 | (0.4, 0.2, 0.3, 0.2, 0.4) | 100,000 | 5 | M1- > (0.3) M2; M1- > (0.9) M2; M1- > (0.3) M2 and M3- > (0.2) M4; M1- > (0.5) M2 and M3- > (0.4) M4 | 0:1 | Non-zero | 70; 500 |
Setting 6 | 0.8 | (0.4, 0.2, 0.3, 0.2, 0.4) | 100,000 | 5 | Independent | 1:3; 1:1 | Non-zero | 70; 500 |
Setting 7 | / | (0.4, 0.2, 0.3, 0.2, 0.4) | 100,000 | 5 | Independent | 0:1 | Zero | 70; 500 |
Setting 8 | 0.8 | (0.4, 0.2, 0.3, 0.2, 0.4) | 100,000 | 5 | Independent | 0:1 | Non-zero | 20; 40; 700 |