Fig. 5
From: A multilayer dynamic perturbation analysis method for predicting ligand–protein interactions
Changes in the shape of the protein pocket. Arrows illustrate the amplitude and direction of motion of the alpha carbon atoms when the human lysozyme (PDB code:1LZS) vibrates along the lowest frequency normal mode, a hinge motion involved in the opening and closing of the catalytic pocket. This conformational change has little effect on the MDPA prediction of the ligand-binding region of this protein