| | +/+ | +/− | −/+ | −/− | p value | R value |
|---|
(a) | | | | | | |
CDX1 | | | | | | |
GPA33 | 43 | 4 | 3 | 28 | 1.03E−13 | 0.81 |
CDX2 | 47 | 0 | 8 | 23 | 2.29E−13 | 0.80 |
CEACAM5-1 | 43 | 4 | 6 | 25 | 6.37E−11 | 0.73 |
VIL1-4 | 42 | 5 | 7 | 24 | 1.98E−09 | 0.68 |
(b) | | | | | | |
Lumen formation | | | | | | |
NRCAM-1 | 12 | 10 | 1 | 19 | 6.38E−04 | 0.53 |
CDX1 | 19 | 3 | 9 | 11 | 7.99E−03 | 0.44 |
CDX2 | 20 | 2 | 11 | 9 | 1.32E−02 | 0.42 |
CEACAM5-1 | 18 | 4 | 9 | 11 | 2.23E−02 | 0.38 |
- The R-values from 2 × 2 association analyses between the genes whose expression is illustrated in Fig. 12. The p-values from the χ2s for each pairwise comparison are all Benjamini–Hochberg corrected. (a) Shows that CDX1 expression is strongly correlated with those of CDX2 and GPA33, a basolateral intestinal differentiation marker, as well as with CEACAM5 and VIL1 which are also colonic epithelial differentiation markers. The association between CDX1 and CDX2 is an inclusion, namely with all CDX1 high being CDX2 high, but not the reverse. (b) Shows the 2 × 2 analyses for the 4 gene expressions that are most highly correlated with lumen formation. Lumen formation is included within CDX1and CDX2 high expression, while NRCAM-1 included within lumen formation
