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Fig. 2 | BMC Bioinformatics

Fig. 2

From: Combining genetic constraint with predictions of alternative splicing to prioritize deleterious splicing in rare disease studies

Fig. 2

Patterns of genic splicing constraint. A The proportion of OR genes, CRISPR Non-essential genes, AR genes, AD genes, and HI genes across the splicing constraint deciles. Color corresponds to the gene set. B The distribution of VG values by splicing constraint deciles (p-value = 2.488e−31). Significance determined using ordinary least squares linear regression. The boxes' interquartile range (IQR) ranges from the 25th to 75th percentile. The horizontal black line in each box represents the median VG value for that decile. The whiskers are 1.5X the IQR. Outliers are not plotted. C The proportion of genes in each splicing constraint decile that had zero significant sOutliers (p-value = 8.832e−06, Adjusted R2 = 0.916). Significance determined using ordinary least squares linear regression. The dark blue line represents the linear regression line. Light blue shade represents the 95% confidence interval. OR Olfactory Receptor, AR Autosomal Recessive, AD Autosomal Dominant, HI Haploinsufficient, sOutliers splicing outliers

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BMC Bioinformatics

ISSN: 1471-2105

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