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Fig. 3 | BMC Bioinformatics

Fig. 3

From: Reconstructing gene regulatory networks of biological function using differential equations of multilayer perceptrons

Fig. 3

Simulate regulator knockout. (1) The perturbed f function can be iterated to simulate the effect of mutants in which specific regulatory chains are deleted. For example, deletion of \(g_3\)’s modulating effect on \(g_3\) leads to an increase in \(g_3\) (from darker to brighter solid green lines), indicating self-inhibition (shown in the third panel). The difference in \(g_2\) levels is not important here (dotted line). A similar argument applies to the other three panel. (2) Describes the sensitivity of network sequence and adapt to the error. Pane shows the knockout technology through links, step 1 to 4 of the evolution process of the network topology. The minimum incoherent feed forward motif appears naturally (topology #4), before the network has too few links to adapt

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