Fig. 4

Comparison between ChiMera and manually curated models of B. subtilis, E. coli, and P. putida. A Venn diagram of reactions and metabolites sets. Reactions and compound sets from ChiMera (iChiMera1182, iChiMera1657, and iChiMera1716) and manually curated models (iYO844, iEC1344_C, and iJN1463) were compared to identify the intersection of the model features. Model-specific information is also depicted. B Heatmap illustrates predicted growth using ChiMera and manually curated models on different experimentally tested growth environments. The models of B. subtilis, E. coli, and P. putida were used to simulate growth on 46, 50, and 70 carbon sources, respectively. These carbon sources and in silico growth rates can be seen in Additional files 2: Tables S4, S5, and S6. The data in heatmap was clustered based on rows and columns