Fig. 1
From: Protein function annotation based on heterogeneous biological networks
The flowchart of PHN method. 1 Constructing the heterogeneous biological network based on original PPI network, domain annotation and protein complex information. 2 Given a testing protein u, running the propagation algorithm on the heterogeneous biological network to obtain the functional similarity score vector pr between u and the other proteins. 3 Scoring and ranking functions in descending order coming from all functional partners and selecting the first L of them as candidates to annotate the target protein