Fig. 3
From: Optimal construction of a functional interaction network from pooled library CRISPR fitness screens
Comparison of top networks. A Schema for enrichment comparison of top scoring networks. Ceres, BF, and Chronos scores were subjected to identical processing pipelines and the resulting networks compared. B Venn diagrams depicting the numbers of genes and edges exclusive to the top 17 k edges in the network created with Ceres + PCAwhitening + PCC versus the top 15 k edges in the network created with BF + PCAwhitening + PCC. C Pearson’s correlation coefficients of common edges, and of exclusive edges to each of the networks (Ceres vs BF). D Venn diagrams depicting the numbers of genes and edges exclusive to the top 17 k edges in the network created with Ceres + PCAwhitening + PCC versus the top 12 k edges in the network created with Chronos + PCAwhitening + PCC. E Pearson’s correlation coefficients of common edges, and of exclusive edges to each of the networks (Ceres vs Chronos). F Enrichment of the gene set exclusive to Ceres + PCAwhitening + PCC (when compared to Chronos). Only the top 30 enriched GO and Kegg terms are listed in the graph