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Table 3 Recovering heart development transcriptional regulators

From: xcore: an R package for inference of gene expression regulators

Top signatures

ISMARA

Lisa

xcore

ReMap2020

ChIP-Atlas

1–10

 

GATA6, SMAD3, GATA4

  

11–50

SNAI2, MEF2A, SRF, GATA4

SMAD1, EOMES, GATA3, SMAD2

SMAD3, NKX2-5, ATF2, TBX5, RBPJ

RARA

51–100

MEF2C, WT1

TBX5, REST, MBD2, TP53, SMAD4

SNAI2

JUN, TP53

  1. Table summarizing heart development-related transcriptional regulators recovered by ISMARA, Lisa and xcore among their top-scoring signatures based on Human H3 embryonic stem cells differentiated to cardiomyocytes time-series dataset. The list of heart development-related transcriptional regulators used to assess the recovery was constructed using Gene Ontology term heart development (GO:0007507) by including only regulators available in the references of all tools
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BMC Bioinformatics

ISSN: 1471-2105

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