Table 3 Comparison between the proposed FVA algorithm and COBRApy FVA algorithm with time to solve on selected problems from the problem set. It should be noted that this time reduction is not uniform, some models such as iAT_PLT_636 and Recon3D show significantly higher reductions in solve time

iAB_RBC_283

0.283

0.437

1.54

iAF1260b

7.230

10.653

1.47

iAT_PLT_636

1.114

3.02

2.71

iEC1356_Bl21DE3

8.791

12.03

1.37

iEC1364_W

9.443

13.02

1.38

iECSP_1301

8.676

11.85

1.37

iIS312_Amastigote

0.355

0.533

1.50

iJN1463

9.980

13.195

1.32

iJO1366

8.450

11.564

1.37

iLB1027_lipid

23.25

32.175

1.38

iLJ478

0.712

0.983

1.38

iMM904

3.465

4.830

1.40

iNJ661

1.538

2.081

1.35

Recon3D

74.86

204.82

2.73