α-level | ST | S2T | AT | GATES | aSPU | sumSTAAR | OWC |
|---|
1 × 10−3 | 1.02 | 1.02 | 1.02 | 1.04 | 1.03 | 0.86 | 1.01 |
1 × 10−4 | 1.00 | 1.03 | 1.00 | 1.03 | 1.02 | 1.10 | 1.04 |
1 × 10−5 | 1.00 | 1.04 | 0.99 | 1.05 | 1.08 | 2.50 | 1.00 |
2.5 × 10−6 | 1.04 | 1.14 | 1.00 | 0.92 | 1.04 | 3.00 | 1.08 |
2.8 × 10−6 | 1.10 | 1.07 | 0.97 | 1.00 | 1.01 | 3.57 | 1.02 |
- Notes: The comparison methods sum test(ST), squared sum test (S2T) and adaptive test (AT) mentioned in the paper are equivalent to the methods burden test (\(L_B\)), the sum of squared score test (\(S_Q\)) and the combination of \(L_B\) and \(S_Q\), respectively. Let \(S_S\) denote the score test and \(L_W\) denote the weighted sum statistic. The proposed combination method OWC is a combination of \(L_B\), \(L_W\), \(S_S\), and \(S_Q\). sumSTAAR is a fexible framework for gene-based association studies using GWAS summary statistics
