Fig. 1From: ShrinkCRISPR: a flexible method for differential fitness analysis of CRISPR-Cas9 screen dataTwo commonly used experimental designs. A a drug sensitizing study compares the effect of gene knockout on paired replicates derived from the same initial sample screened at \(T=0\), which is then split and each part is cultured under a different condition (typically treatment or not). B the comparison of two cell lines typically involves different sgRNA abundances at \(T=0\)Back to article page