Table 1 Summary of main TCR repertoire metrics

Diversity

The richness of the repertoire; the number of different receptors in the population

Important to the immune system given its ability to mount protective immune responses

[14]

Clonality

The frequency of each T cell in the repertoire based on its receptor

Serves as evidence–a form of molecular fingerprint–to identify the origin of certain disorders

[15]

Motif

Short sequence of amino acids which may determine the affinity of a TCR to an antigen

Critical for recognition of certain antigens

[16]

Network

A visual representation in which clones are associated with vertices and edges are associated with a distance measure between two clones

It captures the relationships between the clones and offers a visualization of the repertoire’s structure

[11]