Fig. 5

Molecular docking of the designed vaccine with the TLR4 receptor. A The cartoon representation of the vaccine-TLR4 complex visualized by Discovery Studio Visualizer. B A number of 18 residues of the whole vaccine candidate paired with 15 residues of the TLR-4 ECD. The whole vaccine established 2 salt bridges, 7 hydrogen bonds and 116 non-bonded contacts with the receptor. C The residues involved in interactions among the vaccine and TLR4 ECD are represented as a stick model and colored in red/magenta and blue, respectively, while the vaccine residues are labeled and the interactions are shown with dashed lines