Table 5 Conformational/discontinuous B-cell epitopes in the final construct predicted by Ellipro server

1

G453, P454, G455, P456, G457, K458, V459, L460, A461, G467, K468, T469, Q470, D471, E472, L473, D474, K475, E476, A477, A478, E479, A480, G481, P482, G483, P484, G485, S486, K487, L488, E489, D490, N491, L492, K493, D494, T497, V500, E501, Y503, I504, K505, E506, G507, G508, P509, G510, P511, G512, P513, E514, G515, K516, T517, Q518, D519, E520, L521, D522, K523, E524, A525, A526, E527, D528, A529, N530, I531, E532, A533, L534, Q535, N536, K537, V538, A539, G540, P541, G542, P543, G544, R545, L546, Q547, S548, D549, L550, K551, D552, A553, E554, E555, N556, N557, V558, E559, D560, Y561, V562, K563, E564, G565, L566, G567, P568, G569, P570, G571, A572, P573, K574, P575, E576

2

M1, N2, G3, D4, L6, D8, H9, S10, G11, A12, Y13, V14, A15, Q16, Y18, I19, T20, W21, D22, E23, L24, S25, Y26, N27, H28, Q29, G30, K31, E32, V33, L34, T35, P36, K37, A38, W39, D40, R41, N42, G43, Q44, D45, L46, T47, A48, H49, F50, T51, T52, S53, I54, P55, L56, K57, G58, N59, V60, R61, N62, P88, L89, V90, R91, K92, T100, V110, E111, N112, D113, E114, A115, A116, A117, K118, A119, A120, Q121, A122, A124, K125, G128, L129, T130, P131, P132, S133, T134, D135, H136, Q137, D138, S139, G140, N141, T142, E143, A144, K145, G146, A147, E148, A149, Y151, N152, K155, V173, E174, V175, K176, N177, G178, S179, G180, P181, G182, P183, G184, K185, P186, Q187, T188, E189, K190, P191, E192, E193, D194, K195, E196, H197, D198, E199, V200, S201, E202, P203, T204

3

H586, H589, H590

4

P583, G584, H585

5

A252, Y253, E254, G255, P256, G257, P258, V260, Q261, Y264, G312, P313, G314, P315, G316, K317, G340, G342, P343, G344, K346

6

H205, P206, E207, S208, D209

7

G426, P427, G428, P429, G430

8

Y390, T392, E393, G394, L395, E396, K397, G398, P399, G400, P401

9

E466, Q577, P578, A579, G580

10

T71, G72, L73, A74, F75, W77

11

I348, D349, E350