Table 3 Association of the top three predicted pathways of PriPath with the disease annotated for the study
Dataset accession | Annotated disease | KEGG Pathway ID | DAVID | Reactome | Pathway Name | Literature support for top 3 identified pathways by PriPath |
|---|---|---|---|---|---|---|
GDS1962 | Glioma | hsa05165 | – | – | Human papillomavirus (HPV) infection | The presence of HCMV and HPV has been shown in gliomas. According to one study, HPV infection did not have a significant effect on the prognosis of glioma patients, while another study supports the presence of HPV in gliomas |
hsa04550 | – | – | Signaling pathways regulating pluripotency of stem cells | None found | ||
hsa05131 | – | – | Shigellosis | It can be an opportunistic infection in cancer patients undergoing chemotherapy | ||
GDS2547 | Prostate cancer | hsa04910 | – | – | Insulin signaling pathway | Insulin resistance index is positively correlated with prostate volume in benign prostatic hyperplasia complicated with diabetes patients |
hsa03010 |  +  | – | Ribosome | Ribosome-targeting drugs may be effective against diverse prostate cancer | ||
hsa05171 | – | – | Coronavirus disease | Some research points to a possible liaison between prostate cancer (PCa) and COVID-19 | ||
GDS2609 | Colorectal cancer | hsa04010 | – | – | MAPK signaling pathway | Activation signaling pathways including the MAPK pathway enhance colorectal cancer progression |
hsa04657 | – | – | IL-17 signaling pathway | IL-17A inhibitors have been assessed for their therapeutic and preventative potential in human cancers, particularly in colorectal cancer | ||
hsa05130 | – | – | Pathogenic Escherichia coli infection | Pathogenic E. coli could be a factor in developing colorectal cancer | ||
GDS3268 | Colitis | hsa04151 | – |  +  | PI3K-Akt signaling pathway | Up-regulation of the PI3K/Akt-mTOR signaling pathway can trigger cell apoptosis and inflammation in ulcerative colitis |
hsa05200 | – |  +  | Pathways in cancer | It is known that long duration of ulcerative Colitis is a risk factor for the development of Colitis associated cancers | ||
hsa05164 | – | – | Influenza A | Infection with influenza A could cause hemorrhagic colitis | ||
GDS3646 | Celiac disease | hsa05010 | – | – | Alzheimer disease | Several types of dementia such as Alzheimer’s, vascular dementia, frontotemporal dementia have been association with Celiac disease |
hsa04020 | – | – | Calcium signaling pathway | None found | ||
hsa05012 | – | – | Parkinson disease | PARK7 plays an important role in the preservation of mucosal integrity in Celiac disease | ||
GDS3794 | Arthritis | hsa04620 | – | – | Toll-like receptor signaling pathway | Rheumatoid arthritis (RA) development can be induced by the activation of the Toll-like receptor (TLR) signaling pathway |
hsa04657 | – | – | IL-17 signaling pathway | The IL-17 cytokines play a crucial role in the chronic inflammation of the synovium in psoriatic arthritis | ||
hsa05022 | – | – | Pathways of neurodegeneration—multiple diseases | Neurodegenerative disease increases the progress of arthritis | ||
GDS3837 | Lung cancer | hsa04974 |  +  | – | Protein digestion and absorption | None found |
hsa04510 | – | – | Focal adhesion | FAK is significant in small cell lung cancer biology and targeting its kinase domain may have therapeutic potential | ||
hsa04151 |  +  |  +  | PI3K-Akt signaling pathway | FGF21 may function as a tumor promotor by activating the SIRT1/PI3K/AKT signaling pathway in lung cancer | ||
GDS3874 | Diabetes | hsa05203 | – | – | Viral carcinogenesis | None found |
hsa04625 | – | – | C-type lectin receptor signaling pathway | None found | ||
hsa05166 | – | – | Human T-cell leukemia virus 1 infection | None found | ||
GDS3875 | Diabetes | hsa05168 | – | – | Herpes simplex virus 1(HSV-1) infection | HSV-1 infection has an important association with type 2 diabetes |
hsa04910 | – | – | Insulin signaling pathway | Insulin resistance, is generated by the disruption of the insulin signaling pathway | ||
hsa05022 | – | – | Pathways of neurodegeneration—multiple diseases | One of the conditions which result in neurodegeneration is diabetes | ||
GDS4516 GDS4718 | Colorectal cancer (CRC) | hsa04080 | – | – | Neuroactive ligand-receptor interaction | None found |
hsa04721 | – | – | Synaptic vesicle cycle | None found | ||
hsa04724 | – | – | Glutamatergic synapse | Neuroligin1 is the main component of excitatory glutamatergic synapses complex is verified as a new poor prognostic marker for CRC | ||
GDS4824 | Prostate cancer | hsa04080 | – | – | Neuroactive ligand-receptor interaction | None found |
hsa05163 | – | – | Human cytomegalovirus infection | The activation of the Human cytomegalovirus (HCMV) major immediate early promoter by androgen in the prostate might contribute to oncomodulation in prostate cancers | ||
hsa04062 | – | – | Chemokine signaling pathway | Chemokines play modulatory roles in prostate cancer metastasis | ||
GDS5037 | Asthma | hsa04530 | – | – | Tight junction (TJ) | Asthma may be linked to differential expression of TJ |
hsa05016 | – | – | Huntington’s disease | None found. However, similarly to hsa05022 below, it leads to neurodegeneration | ||
hsa05022 | – | – | Pathways of neurodegeneration—multiple diseases | Asthma, especially when severe, is associated with features of neuroinflammation and neurodegeneration | ||
GDS5499 | Pulmonary Hypertension | hsa04010 | – | – | MAPK signaling pathway | Inhibition of the MAPK axis could prevent vascular remodeling in pulmonary artery hypertension |
hsa04621 | – | – | NOD-like receptor signaling pathway | NOD-like receptor subfamily C3 may potentially be a marker for PH patients | ||
hsa04390 | – | – | Hippo signaling pathway | Pulmonary arterial hypertension is ameliorated by suppressing the HIPPO signaling pathway |