Designing multi-epitope vaccine against important colorectal cancer (CRC) associated pathogens based on immunoinformatics approach

Motamedi, Hamid; Ari, Marzie Mahdizade; Shahlaei, Mohsen; Moradi, Sajad; Farhadikia, Parisa; Alvandi, Amirhoushang; Abiri, Ramin

doi:10.1186/s12859-023-05197-0

Table 3 Most probable predicted epitopes with MHC class I alleles from IEDB analysis tool

From: Designing multi-epitope vaccine against important colorectal cancer (CRC) associated pathogens based on immunoinformatics approach

Protein	Peptide sequence	Start	End	Allele	Score	Antigenicity	Allergenicity	Toxicity
HlpA	SAAAVDAVF	22	30	HLA-B*35:01	0.861527	0.5365	NON-ALLERGEN	Non-Toxin
Bft	KANPKAEGY	280	288	HLA-A*30:02	0.830051	1.0961	NON-ALLERGEN	Non-Toxin
				HLA-B*15:01	0.665572
				HLA-B*57:01	0.615497
				HLA-B*58:01	0.596159
	YPGVMAHEL	333	342	HLA-B*35:01	0.819059	0.6723	NON-ALLERGEN	Non-Toxin
				HLA-B*07:02	0.718513
				HLA-B*53:01	0.716264
				HLA-B*51:01	0.59173
				HLA-B*08:01	0.523581
FadA	QVYNELSQR	66	74	HLA-A*68:01	0.957771	0.8312	NON-ALLERGEN	Non-Toxin
				HLA-A*31:01	0.795891
				HLA-A*11:01	0.657712
				HLA-A*33:01	0.58309
				HLA-A*03:01	0.508062
Fap2	KTISVTAEK	1975	1983	HLA-A*11:01	0.978654	0.7777	NON-ALLERGEN	Non-Toxin
				HLA-A*03:01	0.956606
				HLA-A*30:01	0.866036
				HLA-A*68:01	0.820562
				HLA-A*31:01	0.691021
	FADGLEQRY	3426	3434	HLA-A*01:01	0.972812	1.1206	NON-ALLERGEN	Non-Toxin
				HLA-B*35:01	0.923357
				HLA-B*53:01	0.519186
RadD	GANPSVEYW	304	312	HLA-B*58:01	0.991946	1.1284	NON-ALLERGEN	Non-Toxin
				HLA-B*57:01	0.987697
				HLA-B*53:01	0.73539
	KEQENISQM	58	66	HLA-B*40:01	0.954627	0.4345	NON-ALLERGEN	Non-Toxin
				HLA-B*44:03	0.828703
				HLA-B*44:02	0.783902
superoxide dismutase	YIDVETMHL	18	26	HLA-A*02:06	0.78953	1.3306	NON-ALLERGEN	Non-Toxin
				HLA-A*02:01	0.737224
	TPVLGLDVW	158	166	HLA-B*53:01	0.930286	1.9457	NON-ALLERGEN	Non-Toxin
				HLA-B*35:01	0.50924
Colibactin	YLDALAQQL	2339	247	HLA-A*02:01	0.981781	0.4388	NON-ALLERGEN	Non-Toxin
				HLA-A*02:06	0.926393
				HLA-A*02:03	0.777941
	KADLAQLRY	970	978	HLA-A*01:01	0.970875	0.9347	NON-ALLERGEN	Non-Toxin
				HLA-A*30:02	0.650643
				HLA-B*58:01	0.611357
PCWBR2	YIIQNIYLV	149	157	HLA-A*02:06	0.914671	0.6827	NON-ALLERGEN	Non-Toxin
				HLA-A*02:01	0.884041
				HLA-A*02:03	0.70463
				HLA-A*68:02	0.587899
	RVDTAFAVY	187	195	HLA-A*01:01	0.860066	0.4398	NON-ALLERGEN	Non-Toxin
				HLA-A*30:02	0.801369
				HLA-B*15:01	0.533769
CagA	VPASLSAKL	1050	1058	HLA-B*07:02	0.925163	1.1446	NON-ALLERGEN	Non-Toxin
				HLA-B*35:01	0.668443
				HLA-B*53:01	0.618146
				HLA-B*51:01	0.60881
	GINPEWISK	735	743	HLA-A*11:01	0.904802	1.2858	NON-ALLERGEN	Non-Toxin
				HLA-A*03:01	0.83302
VacA	GEKLVIDEF	600	608	HLA-B*44:03	0.863097	0.4654	NON-ALLERGEN	Non-Toxin
				HLA-B*44:02	0.801589
				HLA-B*40:01	0.72177
	RVNNQVGGY	456	464	HLA-A*30:02	0.84623	1.5337	NON-ALLERGEN	Non-Toxin
				HLA-B*15:01	0.597925

Back to article page

ISSN: 1471-2105

Contact us

General enquiries: journalsubmissions@springernature.com

BMC Bioinformatics

Contact us