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Fig. 5 | BMC Bioinformatics

Fig. 5

From: Gene expression variability across cells and species shapes the relationship between renal resident macrophages and infiltrated macrophages

Fig. 5

Comparative analysis of regulons between human and mouse. A and B Left: Cumulative percentage of regulated DEGs by TFs sorted on the basis of their selectivity. Right: scatterplot showing the number of DEGs regulated by TFs (only TFs regulating < 40 DEGs are shown) and the selectivity of gene regulation for DEGs. The 5 genes with the highest selectivity scores in human are highlighted. C Schematic illustration showing the regulons associated with the 5 TFs with the highest selectivity in human. D Joint clustering of human and mouse renal scRNA-seq data based on the activity of regulons with DEGs as target genes. The branch in which infiltrated macrophages showed a dominant position is shown in bold. E KEGG enrichment of TFs associated with regulons that showed greater evolutionary conservation in infiltrated macrophages. (F) Kidney cells from septic mouse analyzed at the 48-h time point in Dagher’s paper were clustered on the basis of the activity of all the regulons obtained in the original paper. The labels of the cells were based on the clusters described in Dagher’s paper. The branch that is composed mostly of Cluster 4 and Cluster 6 is shown in bold

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