Table 2 Binary classification performance from Leave-One-Molecule-Out Tests for 12 HLA Class I alleles that were assigned different closest models by the default model selection algorithm in MHCnuggets and HLA-Clus
From: HLA-Clus: HLA class I clustering based on 3D structure
LOMO test HLA allelea | Default | HLA-Clus | ||||||
|---|---|---|---|---|---|---|---|---|
Closest modelb | Training set size | Accuracy | Correlation | Closest model | Training set size | Accuracy | Correlation | |
A*32:07 | A*01:01 | 6209 | 0.11 | − 0.09 | A*31:01 | 6280 | 0.32 | 0.19 |
A*68:23 | A*03:01 | 9651 | 0.10 | 0.17 | A*68:01 | 4385 | 0.37 | 0.44 |
B*14:01 | B*27:05 | 4402 | 0.55 | 0.06 | B*14:02 | 223 | 0.60 | 0.55 |
B*15:16 | B*58:01 | 4422 | 0.48 | 0.25 | B*15:17 | 1452 | 0.67 | 0.23 |
B*27:02 | B*27:05 | 4402 | 0.77 | 0.65 | B*27:03 | 912 | 0.67 | 0.27 |
B*27:06 | B*27:05 | 4402 | 0.69 | 0.32 | B*27:20 | 91 | 0.75 | 0.35 |
B*27:20 | B*27:05 | 4402 | 0.46 | 0.69 | B*27:06 | 87 | 0.43 | -0.12 |
B*39:06 | B*27:05 | 4402 | 0.42 | 0.52 | B*39:01 | 1692 | 0.33 | 0.48 |
B*40:13 | B*40:01 | 4337 | 0.29 | 0.30 | B*40:02 | 1087 | 0.26 | 0.20 |
B*57:03 | B*58:01 | 4422 | 0.79 | 0.66 | B*57:01 | 2914 | 0.74 | 0.61 |
B*81:01 | B*07:02 | 6938 | 0.53 | 0.36 | B*42:01 | 218 | 0.73 | 0.48 |
C*08:01 | C*08:02 | 135 | 0.55 | 0.16 | C*03:03 | 164 | 0.75 | 0.40 |
Average | 0.47 | 0.34 | 0.55 | 0.34 | ||||