Fig. 2

Overview of drug mechanism enrichment analysis. DMEA is an adaptation of GSEA which analyzes a rank-ordered drug list to identify drug MOAs that are overrepresented at either end of the input drug list. Given a rank-ordered drug list where drugs have been annotated with known MOAs, DMEA runs an enrichment analysis for each individual MOA. After calculating p values and FDR q-values, DMEA outputs (1) enrichment results for all tested drug MOAs; (2) a volcano plot summarizing the NES and − log₁₀(p value) for all tested drug MOAs; and (3) mountain plot(s) for individual drug MOA(s) which pass the FDR cutoff