Fig. 3
From: Drug mechanism enrichment analysis improves prioritization of therapeutics for repurposing
Sensitivity analysis of DMEA using synthetic data. Synthetic rank-ordered drug lists were generated with varying perturbations (y-axis) of different drug set sizes (x-axis), then analyzed by DMEA (see Methods). For each combination of drug set size and perturbation value, 50 replicates were performed. A Heatmap showing the average DMEA NES for the perturbed drug set. B Heatmap showing the percent of DMEA replicates with FDR q-value < 0.25 for the perturbed drug set