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Fig. 4 | BMC Bioinformatics

Fig. 4

From: Drug mechanism enrichment analysis improves prioritization of therapeutics for repurposing

Fig. 4

DMEA identifies similar MOAs based on gene expression connectivity scores. Rank-ordered drug lists were generated by querying the CMap L1000 gene expression perturbation signatures and then analyzed by DMEA. A HUVEC cells treated with the HMGCR inhibitor pitavastatin [41], B A375 melanoma clones treated with the MEK inhibitor GSK212 [42], and C JEKO1 cells treated with the proteasome inhibitor bortezomib [43]. Volcano plots summarizing the NES and − log10(p value) for all tested drug MOAs and mountain plots of the expected MOAs are shown. Red text indicates MOAs with p value < 0.05 and FDR < 0.25. For each mountain plot, the inhibitors with the most positive connectivity scores are highlighted

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